Crown Aesthetics’ Xycrobe tech study proves skin health “depends on symbiosis”

23 Nov 2022 --- A study on Crown Laboratories’ patented Xycrobe technology is reinforcing its efficacy in topically treating skin conditions and general cosmesis using an isolated, living strain of skin-relevant bacteria with a focus on the skin microbiome.

Xycrobe technology harnesses the power of defendens (C. acnes defendens) – a particular strain of Cutibacterium acnes described in the research as “one of the most prolific skin-specific bacterial species” – to improve skin health and appearance.

Published in the Journal of Cosmetic Dermatology, the clinical study used Biojuve products to provide evidence through in-vitro research supporting the development of novel topicals with formulations derived from symbiotic strains within the skin microbiome. 

“The research we present debunks numerous myths that have perpetuated for the last half century or so about what constitutes a healthy skin microbiome, what role C. acnes strains play in skin health and the ability to formulate progressive topicals with live microbes that might contribute to a healthier skin biome overall,” says Dr. Thomas M. Hitchcock, chief science officer at Crown Laboratories.

“We aim to continue to invest in exploring the relationship between the microbes that live on and in the skin and how this new philosophy of formulating topicals to holistically consider the skin biome may change how we care for the skin.”

Crown Aesthetics unveiled a study substantiating the efficacy of its patented Xycrobe technology.Skin microflora symbiosis
The study highlights growing evidence reinforcing that human health depends on symbiosis with its skin microflora.

C. acnes is said to be “one of the most abundant microbes in the human skin,” accounting for 89% of the bacteria in sebaceous skin follicles. There is a gap in the scientific body of knowledge regarding the role of C. acnes species in skin health and disease.

However, this research elucidates that the protective strains of C. acnes on the skin are not associated with inflammatory issues like acne and can reduce associated symptoms.

According to the research, health-associated C. acnes defendens strains have been observed to have distinct protective characteristics that set them apart. 

Additionally, they can confer significant benefits to the skin through modulation of skin and immune cell activity, secretion of protective substances such as unique bacteriocins, antioxidants, anti-inflammatory cytokines and short-chain fatty acids.

“Traditionally, the medical focus for topical skincare products has always been placed on how any given ingredient may impact the overall health of skin cells with minimal consideration of how the ingredients impact the skin’s microflora or microbiome,” says Dr. Doris Day, board-certified dermatologist and participant in the research study.

“The proven efficacy of this patented Xycrobe technology reinforces the idea that the human body depends on symbiosis. I anticipate this research will diversify the way in which doctors address the health and treatment of skin conditions.”

Studying the efficacy of Xycrobe
The researchers carried out an eight-week study at four locations in the US, including Milwaukee, Harrison, California and Dallas, with female participants between the ages of 18 and 70.The Xycrobe technology addresses the often overlooked skin biome, targeting skin conditions and cosmetic treatments. 

The participants were provided individual regimen kits and instructions on applying the products for the morning and evening routine. 

In the daytime, subjects were instructed to use the prebiotic cleanser, followed by XYCM42 ferment-based serum, moisturizer and sunscreen. At night, subjects used makeup remover (if needed), followed by the prebiotic cleanser, live XYCM42 gel and prebiotic activator.

The researchers carried out a small pilot study of ten subjects over three weeks to test the protective properties of XYCM42. Additionally, they performed a more extensive clinical analysis of 121 participants to assess the benefits of the daily application of XYCM42 and its ferment filtrate.

“The study results assessing skin health parameters indicated that the regimen continues to support a healthy environment as it maintained normal physio-logic pH and transepidermal water loss ranges, increased skin hydration levels, reduced erythema, increased elasticity and an apparent reduction of surface sebum on both the forehead and nose regions,” the results concludes.

Edited by Radhika Sikaria