Greentech taps “skin connectedness” with Holobiosys gentian extract
19 Apr 2023 --- Leveraging research into the holobiont – a collection of species that perform complex interactions in the microbiome – Greentech has launched an active ingredient to treat dry skin.
Holobiosys is the company’s latest achievement following more than 30 years of research into biotechnology, metabolically oriented fermentation, phytochemistry, green extraction, biomimetics and microbiota.
The product is created from a purified extract of organic wild yellow gentian roots (Gentiana lutea), which are sustainably harvested in France by gentian-pickers. The extract is enhanced through an upcycled fermentation process with a rare and cold-tolerant bacteria from aerobiota. The bacteria Sphingomonas sp. can survive in a cold and more desiccated air environment due to specific defense mechanisms.
Connecting skin and microbial ecosystem
To counteract dehydrated (lack of water) and dry (lack of lipids) skin, Holobiosys boosts hyaluronic acid (HA) synthesis in the epidermis and the dermis. It also stimulates HA receptor CD44 and its signaling cascade, reinforcing the epidermal barrier.
With the Holobiosys innovation, Greentech focuses on the connectedness between the various components of the skin and microbiome rather than the individual parts.
Holobiosys is created from a purified organic wild yellow gentian root extract.
With aging or loss of hydration, interactions between the skin and microbiome decrease. By focusing on the microbiota interactions, Holobiosys contributes to a more harmonized holobiont, allowing a deep hydration-restructuring action and reinvigorated, healthier skin, states the company.
Meanwhile, Greentech partnered with GRH Monrad to cultivate exotic plants like Green Chiretta (Andrographis paniculata) to counter the modern lifestyle stressors that disrupt the body’s natural rhythm. The plant, grown by agroforestry, is used for making the ingredient Circalys to enhance the mood and skin from fatigue.
Effective hydration and lipids synthesis
The active ingredient is applied through a systemic method that treats the skin as a whole, repairing dry or dehydrated skin by boosting hyaluronic acid and skin lipids synthesis. The company has used a metaproteomic study focusing on the specific function of each cellular protein to create Holobiosys.
In addition, antioxidant cell responses are upregulated after treatment with the product in keratinocytes and fibroblasts, protecting against hyaluronic acid degradation by free radicals.
Clinically tested on volunteers with dehydrated skin, Holobiosys increased the skin hydration index by 1% after 28 days of application and smoothed wrinkles. It also protected the hydrolipidic film and had a lipid-replenishing effect on a sub-panel presenting dehydrated, sebum-deficient skin.
Edited by Inga de Jong
